Francesco Manelli (Mannelli) (13 September 1594 – July 1667) was a Roman Baroque composer, particularly of opera; and theorbo player. He is most well known for his collaboration with fellow Roman composer Benedetto Ferrari in bringing commercial opera to Venice. The first two works, in 1637 and 1638, to be put on commercially in the Teatro San Cassiano were both by Manelli - his L'Andromeda and La Maga Fulminata.

Francesco Manelli was for many years confused with the Franciscan friar Giovanni Battista Fasolo, because of the resemblances between Manelli’s cantata Luciata, (published in Musiche varie, op. 4 Venice, 1636), and Fasolo’s dialogue Il carro di Madama Lucia (Rome, 1628), and the shared text of the first piece in both collections. In a comparison of the two cantatas Fasolo's version is "languid and melancholy", while Manelli's version is "spirited and biting".